Jimmy Garoppolo ($6,600)
With RBs Raheem Mostert, Jeff Wilson, and Tevin Coleman all injured, I expect the 49ers to lean on Garoppolo this week. Even though WR Deebo Samuel is out, Brandon Aiyuk, Kendrick Bourne, and George Kittle should be more than enough with the creativity of Kyle Shanahan. The Seattle Seahawks are allowing 370 passing yards per game and nearly 29 points per game. In what should be a competitive divisional shootout, Garoppolo should be able to connect with his receivers in the endzone a few times. Brandon Aiyuk ($5,900) is a must-stack at the receiver position if you choose to start Jimmy G.
Darrell Henderson ($6,100)
Given the concentration of fantasy-relevant running backs now, it’s essentially impossible to find a solid budget play. If you can afford Derrick Henry, I would 100% start him against a struggling Bengals defense. That being said, Darrell Henderson Jr ($6,100) presents an interesting option against a bottom-10 run defense in Miami. Admittedly, Henderson has had a rough go of things the past couple weeks, mainly due to a thigh injury he suffered two weeks ago. Henderson also played the 49ers and Bears, which are both top-5 run defenses. He’s still seeing double-digit carries and about 50% of the snaps, which could give him enough opportunity to score a touchdown or two against a porous run defense.
Tyler Boyd ($6,400)
Tyler Boyd is going to be a cheap flex in most of my lineups this week. Last week, Boyd faced the worst defense against slot receivers in the league and scored nearly 30 fantasy points. This week, he faces another bottom-5 defense against the slot position and should see a healthy amount of volume in a game the Bengals are expected to lose by nearly a full touchdown. With no Joe Mixon and a possibly injured Tee Higgins, I expect the Bengals to lean on Tyler Boyd once more.
Jimmy Graham ($5,400)
Similar to the running back position, it really is hard to find safe budget options. I would much rather go with a top-tier tight end like Travis Kelce or Darren Waller. That being said, Graham faces the New Orleans Saints this week and their 31st-ranked defense against opposing tight ends. Graham hasn’t been completely fantasy viable the past few weeks but has faced 3 top-10 tight end defenses in a row. He’s shown the potential for a big game like he did against the soft Atlanta Falcons defense a few weeks back. With Allen Robinson potentially unavailable, Nick Foles will be struggling to find open players. I think Graham becomes a safe play based purely off of volume, although he might be able to find his way to a touchdown (or maybe two).